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This agent is a new broad spectrum antibacterial drug active against most Gram-negative, Gram-positive bacteria, and some anaerobes . Its bacterial action is based on its anti-DNA gyrase activity .
This broad spectrum of antibacterial activity and widespread distribution to most tissues and body uids at relatively high concentrations after oral administration have made this drug useful for the Ecl. Ornidazole ORN g.
It is used for the treatment and prophylaxis of infections, which is induced by anaerobic and microaerophilic bacteria and protozoa .
Combinations of ooxacin and ornidazole are available in the market, which are highly active against many bacterial infections of enteritis and anaerobic bacteria .
Subsequent Artigo Article Artigo Article plasma concentrations of Ooxacin are obtained in hours after oral administration. Peak plasma concentrations of Ornidazole are obtained within 2 hours of administration.
Because of the critical nature of the rst two of these steps, in vitro dissolution may be relevant to the prediction of in vivo performance . The dissolution test is a very important tool in drug development and quality control. For QC, an over-discriminatory test might be suitable to detect even small production deviations. However, for prediction of the in vivo performance of drug product a dissolution test should be sensitive and reliable .
When dissolution test is not dened in the monograph of the dosage form, or if the monograph is not available, the selection of a dissolution medium may be based on the solubility data and dosage range of the drug product .
Hydrochloric acid is typical medium used to dissolution test , and 0. The assay procedure mentioned in these pharmacopoeias is non aqueous titration. There are many reported HPLC , UV spectrophotometry  and spectrouorimetry methods for the estimation of these drugs from pharmaceutical preparations and biological uids, and also the analytical methods are available for stability  studies of these drugs.
ORN is ofcial in none of the Pharmacopoeias. At present, there are no ofcial monographs for OFL and ORN dosage forms and no dissolution tests have been described in literature.
Parameters to set up the dissolution test should be researched and dened for drugs that do not possess ofcial monographs . The present paper describes the development and validation of analytical methods for the estimation and dissolution test for OFL and ORN tablet dosage form.
The best dissolution conditions were used to evaluate the dissolutions testing of three different brands of tablets. All reagents and solvents used were analytical grade. The content was sonicated for 10min; nally the volume made up to the mark with 0. Customer Reviews Write a Review.
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